Down Syndrome Risk - Results
At age 32, the chance of Down syndrome is about 1 in 760. This means that out of 760 pregnancies at this age, approximately 759 will not be affected. Your risk is below the 1 in 250 clinical threshold used to determine whether diagnostic testing is routinely recommended.
Risk by Maternal Age
Down Syndrome Risk by Maternal Age
| Age | At Birth | At 16 Weeks | At 12 Weeks |
|---|---|---|---|
| 20 | 1 in 1,484 | 1 in 1,206 | 1 in 1,038 |
| 21 | 1 in 1,471 | 1 in 1,196 | 1 in 1,028 |
| 22 | 1 in 1,453 | 1 in 1,181 | 1 in 1,016 |
| 23 | 1 in 1,430 | 1 in 1,163 | 1 in 1,000 |
| 24 | 1 in 1,401 | 1 in 1,139 | 1 in 980 |
| 25 | 1 in 1,363 | 1 in 1,108 | 1 in 953 |
| 26 | 1 in 1,316 | 1 in 1,070 | 1 in 920 |
| 27 | 1 in 1,256 | 1 in 1,021 | 1 in 879 |
| 28 | 1 in 1,184 | 1 in 962 | 1 in 828 |
| 29 | 1 in 1,097 | 1 in 892 | 1 in 767 |
| 30 | 1 in 996 | 1 in 809 | 1 in 696 |
| 31 | 1 in 882 | 1 in 717 | 1 in 617 |
| 32 | 1 in 760 | 1 in 618 | 1 in 531 |
| 33 | 1 in 635 | 1 in 516 | 1 in 444 |
| 34 | 1 in 514 | 1 in 418 | 1 in 359 |
| 35 | 1 in 403 | 1 in 328 | 1 in 282 |
| 36 | 1 in 308 | 1 in 251 | 1 in 216 |
| 37 | 1 in 232 | 1 in 188 | 1 in 162 |
| 38 | 1 in 172 | 1 in 140 | 1 in 121 |
| 39 | 1 in 129 | 1 in 105 | 1 in 90 |
| 40 | 1 in 98 | 1 in 80 | 1 in 68 |
| 41 | 1 in 76 | 1 in 62 | 1 in 53 |
| 42 | 1 in 61 | 1 in 49 | 1 in 43 |
| 43 | 1 in 50 | 1 in 41 | 1 in 35 |
| 44 | 1 in 43 | 1 in 35 | 1 in 30 |
| 45 | 1 in 38 | 1 in 31 | 1 in 26 |
| 46 | 1 in 34 | 1 in 28 | 1 in 24 |
| 47 | 1 in 31 | 1 in 25 | 1 in 22 |
| 48 | 1 in 29 | 1 in 24 | 1 in 20 |
| 49 | 1 in 28 | 1 in 23 | 1 in 19 |
Risk at earlier gestational ages is higher because approximately 23-30% of Down syndrome pregnancies end in miscarriage between the first trimester and birth. Data based on Morris et al (2002) and Savva et al (2006).
Related Pregnancy Tools
This calculator provides statistical estimates based on maternal age only and is not a medical diagnosis. Risk figures represent population averages and do not predict the outcome of any individual pregnancy. Screening results should always be discussed with your healthcare provider or a genetic counselor. Sources: Morris, Mutton & Alberman, J Med Screen 9:1, 2002. Hook EB, JAMA 249:2034, 1983. Savva et al, Prenat Diagn 26:5, 2006. ACOG Practice Bulletin.